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How Tadalafil Works

Before we explain how Tadalafil helps manage ED, we need to explain how erections occur naturally. When you become aroused, your body releases a substance called nitric oxide (NO). In turn, levels of a chemical known as cyclic guanosine monophosphate (cGMP) increase in your body, relaxing the muscles on the sides of your penis so blood can flow into the organ and trigger a stiff erection.

While all this is happening, your body also compresses the veins that take blood away from the penis, so that the blood remains in place and you can maintain that erection. Eventually, the PDE5 enzyme in your body gets to work, and it processes the cGMP. When that happens, your erection dissipates, and the penis becomes flaccid once again.

If you have ED, regardless of the underlying cause, this natural process is somehow interrupted. That makes it more difficult for you to get or maintain an erection that’s sufficient for intercourse. And that’s where Tadalafil, a PDE5 inhibitor, can help. By blocking this enzyme in your body, you’ll have an easier time getting an erection and holding on to it until sex is complete.

As we mentioned earlier, ED can be caused by various factors, so before we get too too personal, let’s talk about what Tadalafil is. Tadalafil is a prescription medication specifically designed to treat ED. It’s available in two forms: a generic version of Cialis (also available as a brand-name medication called Tadalafil) called Tadalafil and a brand-name version called Sildenafil. When taking Tadalafil, it’s important to take it as prescribed, to ensure that it’s getting to the right parts of your body like your penis and the brain.

When you get ED, you’re flooded with blood. That’s the signal that cyclic guanosine monophosphate (cGMP) is sending to the penis. cGMP relaxes the smooth muscle in the penis, causing blood to flow into the penis. That leads to an increased inflow of blood into the penis, which is necessary for an erection to be effective.

Now that we’re getting more of a step closer to explaining how Tadalafil works, let’s talk about some common ED treatments that Tadalafil is good for.

1. Viagra

If you are considering taking Viagra, you should be considering all of the treatments available to treat your ED. All of the treatments mentioned here work very similarly to Tadalafil. However, you should be aware that Tadalafil may not be the best option for you if you have other conditions like heart problems or high blood pressure.

All of the treatments mentioned here may not be suitable for everyone. So if you have any of these conditions, you should talk to your doctor before taking Tadalafil.

All of the treatments mentioned here may not work for everyone. So if you are considering other treatments for ED, you should talk to your doctor before taking Tadalafil.

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2. Tadalafil (Cialis)

The term “tadalafil” is short for “IFEQUIN®, a generic form of Levitra® (vardenafil).” Like Viagra, tadalafil contains vardenafil, which works by relaxing the muscles in the penis. This allows blood to flow into the penis and cause an erection when you are sexually stimulated. When taken as prescribed, tadalafil is highly effective in treating ED.

While all of the treatments mentioned here can be effective for most men, there are some specific ED treatments that may not work for everyone. So if you are considering other treatments for ED, you should talk to your doctor before taking tadalafil.

3.

How Tadalafil Works

Before we explain how Tadalafil helps manage ED, we need to explain how erections occur naturally. When you become aroused, your body releases a substance called nitric oxide (NO). In turn, levels of a chemical known as cyclic guanosine monophosphate (cGMP) increase in your body, relaxing the muscles on the sides of your penis so blood can flow into the organ and trigger a stiff erection.

While all this is happening, your body also compresses the veins that take blood away from the penis, so that the blood remains in place and you can maintain that erection. Eventually, the PDE5 enzyme in your body gets to work, and it processes the cGMP. When that happens, your erection dissipates, and the penis becomes flaccid once again.

If you have ED, regardless of the underlying cause, this natural process is somehow interrupted. That makes it more difficult for you to get or maintain an erection that’s sufficient for intercourse. And that’s where Tadalafil, a PDE5 inhibitor, can help. By blocking this enzyme in your body, you’ll have an easier time getting an erection and holding on to it until sex is complete.

As we mentioned earlier, erections last up to 36 hours. That’s great if you’re planning on having sex, but that’s not the only advantage you’ll have if you’re sexually active. If you’re interested in learning more about this natural process, you can read about it.

How Tadalafil Works with Erections

As already mentioned, you’ll be able to get an erection by taking Tadalafil with or without food. When you take Tadalafil, it starts working gradually. That means that if you take it with food, Tadalafil can help you get an erection quickly. But if you take it with food, it may take a little longer to get the results you need.

If you have ED, this same principle applies to your PDE5 inhibitor. If you have ED that’s caused by something else, Tadalafil won’t be able to help you.

So if you have ED and you take Tadalafil, you can either get an erection by taking it with or without food, or you can get an erection by getting an oral erection tablet from a reputable online pharmacy. Because when you take it with food, it can help you get an erection, but if you take it with food, it may take a little longer to get the results you need.

When you get an erection, you have an interaction with your partner. They’re more likely to get it if you’re involved. That means that when you become sexually aroused, your body compresses the veins that take blood away from your penis, and that means that when you get an erection, you have an interaction with your partner.

That interaction can make it more difficult for you to get an erection. And that’s where Tadalafil, a PDE5 inhibitor, comes in. When Tadalafil, a PDE5 inhibitor, works, it can make it more difficult for you to get an erection.

If you have ED and you take Tadalafil, you can either get an erection by taking it with or without food, or you can get an erection by getting an oral erection tablet from a reputable online pharmacy. Because when you take it with food, Tadalafil can help you get an erection, but if you take it with food, it may take a little longer to get the results you need.

If you have ED and you take Tadalafil, you have a process called. When that happens, you have an interaction with your partner. That means when you become sexually aroused, your body compresses the veins that take blood away from your penis, and that means that when you get an erection, you have an interaction with your partner.

And that’s the main difference between Tadalafil and Viagra.

If you have ED and you take Tadalafil, you have a process called called. That’s the same process that makes it more difficult for you to get an erection.

They’re more likely to get it.

Drug Interaction of Tadalafil and Sildenafil

Drug-Drug Interaction

Tadalafil and Sildenafil

There is no special use of this drug against you.

Sildenafil

You should keep using this drug and your doctor know you are taking it.

Tadalafil

Sildenafil is a drug that may interact with:

  • Hepatotoxicity (low liver function tests) in the liver, including to the kidney, heart, and blood circulation.
  • Use in the blood & kidneys.

The use of this drug in the liver or lungs, in the brain, or in the skin may lead to a lowering of your blood pressure.

Drug-Food Interaction

You should avoid the consumption of fatty foods while taking this drug.

Drug-Disease Interaction

You should avoid the use of this drug if you have:

  • A tumor in the liver or the liver disease.
  • Inhibitors of Tadalafil (Cialis, Viagra, Levitra, Staxyn, Stendra, and StendraC), other drugs that affect the enzyme phosphodiesterase type 5 (PDE5).
  • If you have AIDS (AIDS, HIV, gonorrhea, syphilis).

Method of Imposition of Sildenafil

Sildenafil is a drug that is administered by oral route in tablets, suspensions, and capsules.

Disease Interaction

You should avoid the use of this drug if you are suffering from:

  • Pulmonary hypertension (pyloriosis) in patients who are taking nitrates (for chest pain, angina, or shortness of breath).
  • Anuria in patients who take drugs for an enlarged prostate gland (benign prostatic hyperplasia).
  • Prostate cancer in patients with liver or kidney disease who take other drugs for liver disease or heart disease (see side effects).

  • Inhibitors of Tadalafil (Cialis, Viagra, Levitra, Staxyn, StendraC), other drugs that affect the enzyme phosphodiesterase type 5 (PDE5).

Drug-Dosage and Administration

Sildenafil is taken only with a glass of water.

Dosage and Administration

The recommended dose of sildenafil in case of the following recommendations:

This dose is taken one hour before the sexual intercourse. Take it with a full glass of water.

Pregnancy & Lactation

This drug is not recommended for use in the human body. However, it may be available as a capsule and tablet.

Pregnant women should avoid the consumption of this drug.

The use of this drug in the human body is contraindicated in women who are suffering from an enlarged prostate gland.

Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

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Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tadalafil for ED[

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This medicine is for you. It is not recommended to take it along with medicines called alpha-blockers (used to treat pulmonary arterial hypertension). Tadalafil may cause low blood pressure in people with diabetes. Check your diabetes blood pressure regularly.

You should not take this medicine if you have high blood pressure ( combination of these two).

Do not give this medicine to other children or adolescents as it may cause harm to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

CMP Number: USCAReford Healthcare Private Ltd96620-6322-9662.1507-0583/CMP/CMP039030. HELPCiplab Inc. KDDCE.